Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ Bortezomib
Bortezomib, CAS 179324-69-7, is a cell-permeable, selective, slowly reversible inhibitor of 20S proteasome β5 ChTL/chymotrypsin- over β1 CL/caspase- and β2 TL/trypsin-like activity.
MilliporeSigma™ Calbiochem™ CD40-TRAF6 Signaling Inhibitor, 6877002
A cell-permeable compound that specifically targets TRAF6 (Kd = 97 μM for TRAF6 C-domain) and disrupts its functional coupling with CD40.
MilliporeSigma™ Calbiochem™ Picrotoxin, Anamirta cocculin
A potent antagonist of GABA receptors (IC50 = 240 nM) at synapses in the central nervous system.
MilliporeSigma™ Calbiochem™ Autophagy Inducer, STF-62247
A cell-permeable autophagy inducer that selectively induces non-apoptotic cell death in VHL-deficient, but not VHL-expressing, renal carcinoma cells both in vitro and in mice in vivo.
MilliporeSigma™ Calbiochem™ Methotrexate
Inhibits thymidylate synthetase, is a nonselective de novo purine synthesis inhibitor, and has a significant toxicity profile including hepatotoxicity, pneumonitis, and bone marrow suppress
MilliporeSigma™ Calbiochem™ p-Nitroblue Tetrazolium Chloride
NADPH-diaphorase substrate that competitively inhibits nitric oxide synthase (IC50 = 3-4 μM).
MilliporeSigma™ Calbiochem™ Calmodulin Kinase IINtide, Myristoylated
The myristoylated form of CaMK IINtide.
MilliporeSigma™ Calbiochem™ Akt Inhibitor II
The Akt Inhibitor II controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ QX-314
A quaternary lidocaine derivative, permanently charged, and lipophobic.
MilliporeSigma™ Calbiochem™ SUMOylation Inhibitor III, 2-D08
A cell-permeable compound that prevents the transfer of SUMO from the E2 thioester to the substrate without affecting SUMO-activating enzyme E1 (SAE-1/2) or E2 Ubc9-SUMO thioester formation.
MilliporeSigma™ Calbiochem™ (+)-Blebbistatin
The inactive enantiomer of (±)-Blebbistatin.
MilliporeSigma™ Calbiochem™ PME-1 Inhibitor, AMZ-30
The PME-1 Inhibitor, AMZ-30 controls the biological activity of PME-1. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
MilliporeSigma™ Calbiochem™ APE1 Inhibitor III
The APE1 Inhibitor III controls the biological activity of APE1. This small molecule/inhibitor is primarily used for Cell Structure applications.
MilliporeSigma™ Calbiochem™ Deoxyhypusine Synthase Inhibitor, GC7
The Deoxyhypusine Synthase Inhibitor, GC7, also referenced under CAS 150333-69-0, controls the biological activity of Deoxyhypusine Synthase.
